Synthesis and biological evaluation of geldanamycin–ferulic acid conjugate as a potent Hsp90 inhibitor

A novel geldanamycin–ferulic acid conjugate LZY228 was prepared and evaluated for anti-proliferation activity on human cancer cell line MDA-MB-231. Compound LZY228 exhibited potent cytotoxicity with IC(50) value of 0.27 μM, which was more potent than 17-AAG. Hepatotoxicity test in mice demonstrated...

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Detalles Bibliográficos
Autores principales: Li, Zhenyu, Jia, Lejiao, Tang, Hui, Shen, Yuemao, Shen, Chengwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076653/
https://www.ncbi.nlm.nih.gov/pubmed/35542888
http://dx.doi.org/10.1039/c9ra08665j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076653/
https://www.ncbi.nlm.nih.gov/pubmed/35542888
http://dx.doi.org/10.1039/c9ra08665j

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