Cargando…

Synthesis and biological evaluation of geldanamycin–ferulic acid conjugate as a potent Hsp90 inhibitor

A novel geldanamycin–ferulic acid conjugate LZY228 was prepared and evaluated for anti-proliferation activity on human cancer cell line MDA-MB-231. Compound LZY228 exhibited potent cytotoxicity with IC(50) value of 0.27 μM, which was more potent than 17-AAG. Hepatotoxicity test in mice demonstrated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Zhenyu, Jia, Lejiao, Tang, Hui, Shen, Yuemao, Shen, Chengwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076653/ https://www.ncbi.nlm.nih.gov/pubmed/35542888 http://dx.doi.org/10.1039/c9ra08665j

Ejemplares similares

LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model
por: Li, Zhenyu, et al.
Publicado: (2023)

Development of the first geldanamycin-based HSP90 degraders
por: Wurnig, Silas, et al.
Publicado: (2023)

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors – potential therapeutics in cancer and neurodegeneration
por: Kitson, Russell R. A., et al.
Publicado: (2013)

HSP90 Inhibitor Geldanamycin as a Radiation Response Modificator in Human Blood Cells
por: Stankova, Katia, et al.
Publicado: (2015)

17-ABAG, a novel geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition
por: LIN, ZHIYUAN, et al.
Publicado: (2015)

A docking-based structural analysis of geldanamycin-derived inhibitor binding to human or Leishmania Hsp90
por: Palma, Luana Carneiro, et al.
Publicado: (2019)

HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells
por: Wu, Ming-Shun, et al.
Publicado: (2013)

The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments
por: Cortese, Katia, et al.
Publicado: (2013)

The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin
por: Kumar, Rajinder, et al.
Publicado: (2003)

Study of interaction energies between residues of the active site of Hsp90 and geldanamycin analogues using quantum mechanics/molecular mechanics methods
por: Vivas-Reyes, Ricardo, et al.
Publicado: (2020)

Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
por: Sha, Longze, et al.
Publicado: (2020)

Development and Characterization of PLGA Nanoparticles Containing 17-DMAG, an Hsp90 Inhibitor
por: Cruz, Kercia P., et al.
Publicado: (2021)

Discovery of potent heat shock protein 90 (Hsp90) inhibitors: structure-based virtual screening, molecular dynamics simulation, and biological evaluation
por: Xu, Yonghua, et al.
Publicado: (2023)

Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells
por: ZITZMANN, KATHRIN, et al.
Publicado: (2013)

Hsp-90 and the biology of nematodes
por: Him, Nik AIIN, et al.
Publicado: (2009)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B
por: Lu, Zhiyuan, et al.
Publicado: (2020)

Degradable Cross-Linked Nanoassemblies as Drug Carriers for Heat Shock Protein 90 Inhibitor 17-N-Allylamino-17-demethoxy-geldanamycin
por: Ponta, Andrei, et al.
Publicado: (2011)

In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi
por: Wenkert, David, et al.
Publicado: (2010)

2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90
por: Kamm, Anna, et al.
Publicado: (2019)

Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex
por: Qin, Shurong, et al.
Publicado: (2022)

Novel 4-Acrylamido-Quinoline Derivatives as Potent PI3K/mTOR Dual Inhibitors: The Design, Synthesis, and in vitro and in vivo Biological Evaluation
por: Ma, Xiaodong, et al.
Publicado: (2019)

Geldanamycin attenuates 3-nitropropionic acid-induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells
por: CHOI, YONG-JOON, et al.
Publicado: (2014)

Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin
por: Liu, D, et al.
Publicado: (2002)

Catalysis-Enabled Access to Cryptic Geldanamycin Oxides
por: Hilton, Margaret J., et al.
Publicado: (2020)

The nuclear export inhibitor aminoratjadone is a potent effector in extracellular-targeted drug conjugates
por: Klahn, Philipp, et al.
Publicado: (2019)

Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity
por: Siddiqui, Farid A., et al.
Publicado: (2021)

Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy
por: Pan, Xin, et al.
Publicado: (2022)

Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)
por: Gorska, Magdalena, et al.
Publicado: (2013)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

A New Geldanamycin Analogue from Streptomyces hygroscopicus
por: Zhang, Hao, et al.
Publicado: (2010)

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
por: Kuroyanagi, Gen, et al.
Publicado: (2022)

Synthesis and biological evaluation of biotin-conjugated Portulaca oleracea polysaccharides
por: Han, Qianqian, et al.
Publicado: (2021)

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
por: Woodford, Mark R., et al.
Publicado: (2016)

New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation
por: Bokhtia, Riham M., et al.
Publicado: (2023)

Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia
por: Khajapeer, Kalubai Vari, et al.
Publicado: (2015)

Hsp90 Inhibitor Can Inhibit UV-Carcinogenesis
por: Katiyar, Santosh K.
Publicado: (2015)

Circumventing HSP90 inhibitors via apoptosis block
por: Fennell, Dean A., et al.
Publicado: (2015)

Identification and characterization of the antiplasmodial activity of Hsp90 inhibitors
por: Murillo-Solano, Claribel, et al.
Publicado: (2017)

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors
por: Nizami, Sohaib, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5ppdb3nmgcbdcn9hldrs7c6jrn