XBP1 maintains beta cell identity, represses beta-to-alpha cell transdifferentiation and protects against diabetic beta cell failure during metabolic stress in mice

AIMS/HYPOTHESIS: Pancreatic beta cell dedifferentiation, transdifferentiation into other islet cells and apoptosis have been implicated in beta cell failure in type 2 diabetes, although the mechanisms are poorly defined. The endoplasmic reticulum stress response factor X-box binding protein 1 (XBP1)...

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Detalles Bibliográficos
Autores principales: Lee, Kailun, Chan, Jeng Yie, Liang, Cassandra, Ip, Chi Kin, Shi, Yan-Chuan, Herzog, Herbert, Hughes, William E., Bensellam, Mohammed, Delghingaro-Augusto, Viviane, Koina, Mark E., Nolan, Christopher J., Laybutt, D. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076738/
https://www.ncbi.nlm.nih.gov/pubmed/35316840
http://dx.doi.org/10.1007/s00125-022-05669-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076738/
https://www.ncbi.nlm.nih.gov/pubmed/35316840
http://dx.doi.org/10.1007/s00125-022-05669-7

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