Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer

IRE1α is constitutively active in several cancers and can contribute to cancer progression. Activated IRE1α cleaves XBP1 mRNA, a key step in production of the transcription factor XBP1s. In addition, IRE1α cleaves select mRNAs through regulated IRE1α-dependent decay (RIDD). Accumulating evidence imp...

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Detalles Bibliográficos
Autores principales: Almanza, Aitor, Mnich, Katarzyna, Blomme, Arnaud, Robinson, Claire M., Rodriguez-Blanco, Giovanny, Kierszniowska, Sylwia, McGrath, Eoghan P., Le Gallo, Matthieu, Pilalis, Eleftherios, Swinnen, Johannes V., Chatziioannou, Aristotelis, Chevet, Eric, Gorman, Adrienne M., Samali, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076827/
https://www.ncbi.nlm.nih.gov/pubmed/35524156
http://dx.doi.org/10.1038/s41467-022-30159-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076827/
https://www.ncbi.nlm.nih.gov/pubmed/35524156
http://dx.doi.org/10.1038/s41467-022-30159-0

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