The AMPK-related kinase NUAK2 suppresses glutathione peroxidase 4 expression and promotes ferroptotic cell death in breast cancer cells

Ferroptosis is a caspase-independent form of regulated cell death strongly linked to the accumulation of reactive lipid hydroperoxides. Lipid hydroperoxides are neutralized in cells by glutathione peroxidase 4 (GPX4) and inhibitors of GPX4 are potent ferroptosis inducers with therapeutic potential i...

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Detalles Bibliográficos
Autores principales: Singh, Tanu, Beatty, Alexander, Peterson, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076840/
https://www.ncbi.nlm.nih.gov/pubmed/35523770
http://dx.doi.org/10.1038/s41420-022-01044-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076840/
https://www.ncbi.nlm.nih.gov/pubmed/35523770
http://dx.doi.org/10.1038/s41420-022-01044-y

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