Optimization of IL-1RA structure to achieve a smaller protein with a higher affinity to its receptor

Interleukine-1 family cytokines are key orchestrators of innate and adaptive immunity. In particular, up-regulation of IL-1R1 via its agonistic ligands consisting of IL-1β and IL-1α is implicated in a variety of human diseases, such as rheumatoid arthritis, psoriasis, type I diabetes, amyotrophic la...

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Detalles Bibliográficos
Autores principales: Nouri Barkestani, Mahsa, Naserian, Sina, Khoddam, Fatemeh, Shamdani, Sara, Bambai, Bijan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076856/
https://www.ncbi.nlm.nih.gov/pubmed/35523814
http://dx.doi.org/10.1038/s41598-022-11100-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076856/
https://www.ncbi.nlm.nih.gov/pubmed/35523814
http://dx.doi.org/10.1038/s41598-022-11100-3

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