A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis

The level of glutathione (GSH) is increased in many cancer cells. Consuming intracellular GSH by chemical small molecules that specifically target GSH is a new strategy to treat cancer. Recently, we synthesized and proved that a new compound 2-(7-(diethylamino)-2-oxo-2H-chromen-3-yl)cyclohexa-2,5-di...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, LiHong, Qu, GuoJing, Gao, YuanDi, Su, Le, Ye, Qing, Jiang, Fan, Zhao, BaoXiang, Miao, JunYing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076930/
https://www.ncbi.nlm.nih.gov/pubmed/35538996
http://dx.doi.org/10.1039/c7ra11935f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9076930/
https://www.ncbi.nlm.nih.gov/pubmed/35538996
http://dx.doi.org/10.1039/c7ra11935f

Ejemplares similares