Identification of 1,2,4-Oxadiazoles-Based Novel EGFR Inhibitors: Molecular Dynamics Simulation-Guided Identification and in vitro ADME Studies

BACKGROUND: In this work, we have identified heterocyclic derivatives with 1,2,4 oxadiazole scaffold mimicking the functions of tyrosine kinase inhibitors. Fourteen molecules that displayed the best fit were picked from the library of compounds and studied under in-silico and in-vitro conditions. Fo...

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Detalles Bibliográficos
Autores principales: Unadkat, Vishal, Rohit, Shishir, Parikh, Paranjay, Patel, Kaushal, Sanna, Vinod, Singh, Sanjay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077134/
https://www.ncbi.nlm.nih.gov/pubmed/35535170
http://dx.doi.org/10.2147/OTT.S357765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077134/
https://www.ncbi.nlm.nih.gov/pubmed/35535170
http://dx.doi.org/10.2147/OTT.S357765

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