Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors

Herein we describe the design, synthesis, and biological evaluation of a novel series of tranylcypromine-based LSD1 inhibitors via conformational restriction using spiro ring systems. A simple, direct spirocyclic analog of tranylcypromine (compounds 8a and 8b) was shown to be a 28- to 129-fold more...

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Detalles Bibliográficos
Autores principales: Shi, Ying, Wu, Yan-Ran, Su, Ming-Bo, Shen, Dong-Hao, Gunosewoyo, Hendra, Yang, Fan, Li, Jia, Tang, Jie, Zhou, Yu-Bo, Yu, Li-Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077246/
https://www.ncbi.nlm.nih.gov/pubmed/35540911
http://dx.doi.org/10.1039/c7ra13097j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077246/
https://www.ncbi.nlm.nih.gov/pubmed/35540911
http://dx.doi.org/10.1039/c7ra13097j

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