Venetoclax enhances DNA damage induced by XPO1 inhibitors: A novel mechanism underlying the synergistic antileukaemic effect in acute myeloid leukaemia

Acute myeloid leukaemia (AML) is a highly heterogeneous haematologic malignancy with poor prognosis. We previously showed synergistic antileukaemic interaction between exportin 1 (XPO1) inhibitor KPT‐330 (Selinexor) and Bcl‐2 inhibitor venetoclax (ABT‐199) in preclinical models of AML, which was par...

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Detalles Bibliográficos
Autores principales: Yu, Hanxi, Wu, Shuangshuang, Liu, Shuang, Li, Xinyu, Gai, Yuqing, Lin, Hai, Wang, Yue, Edwards, Holly, Ge, Yubin, Wang, Guan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077288/
https://www.ncbi.nlm.nih.gov/pubmed/35355406
http://dx.doi.org/10.1111/jcmm.17274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077288/
https://www.ncbi.nlm.nih.gov/pubmed/35355406
http://dx.doi.org/10.1111/jcmm.17274

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