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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only antibodies (VHHs or single domain antibody fragments) targeting Tau as immuno-modulators of its pathologic seeding. A...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077319/ https://www.ncbi.nlm.nih.gov/pubmed/35007758 http://dx.doi.org/10.1016/j.ymthe.2022.01.009 |