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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only antibodies (VHHs or single domain antibody fragments) targeting Tau as immuno-modulators of its pathologic seeding. A...

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Detalles Bibliográficos
Autores principales: Danis, Clément, Dupré, Elian, Zejneli, Orgeta, Caillierez, Raphaëlle, Arrial, Alexis, Bégard, Séverine, Mortelecque, Justine, Eddarkaoui, Sabiha, Loyens, Anne, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Buée, Luc, Landrieu, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077319/
https://www.ncbi.nlm.nih.gov/pubmed/35007758
http://dx.doi.org/10.1016/j.ymthe.2022.01.009