Cargando…

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only antibodies (VHHs or single domain antibody fragments) targeting Tau as immuno-modulators of its pathologic seeding. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Danis, Clément, Dupré, Elian, Zejneli, Orgeta, Caillierez, Raphaëlle, Arrial, Alexis, Bégard, Séverine, Mortelecque, Justine, Eddarkaoui, Sabiha, Loyens, Anne, Cantrelle, François-Xavier, Hanoulle, Xavier, Rain, Jean-Christophe, Colin, Morvane, Buée, Luc, Landrieu, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077319/ https://www.ncbi.nlm.nih.gov/pubmed/35007758 http://dx.doi.org/10.1016/j.ymthe.2022.01.009

Ejemplares similares

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies
por: Leroux, Elodie, et al.
Publicado: (2022)

Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
por: Dujardin, Simon, et al.
Publicado: (2014)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody
por: Albert, Marie, et al.
Publicado: (2019)

Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies
por: Dujardin, Simon, et al.
Publicado: (2014)

Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes
por: Bretteville, Alexis, et al.
Publicado: (2009)

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies
por: Tardivel, Meryem, et al.
Publicado: (2016)

Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
por: Cantrelle, François-Xavier, et al.
Publicado: (2021)

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects
por: Barbier, Pascale, et al.
Publicado: (2019)

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation
por: Lasorsa, Alessia, et al.
Publicado: (2018)

Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin
por: Mansuroglu, Zeyni, et al.
Publicado: (2016)

Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents
por: Rico, Thomas, et al.
Publicado: (2022)

Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System
por: Perbet, Romain, et al.
Publicado: (2023)

Direct Crosstalk Between O-GlcNAcylation and Phosphorylation of Tau Protein Investigated by NMR Spectroscopy
por: Bourré, Gwendoline, et al.
Publicado: (2018)

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate
por: Lam, Suzanne, et al.
Publicado: (2021)

Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process
por: Domise, Manon, et al.
Publicado: (2019)

Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
por: Papegaey, Anthony, et al.
Publicado: (2016)

A Novel Tau Antibody Detecting the First Amino-Terminal Insert Reveals Conformational Differences Among Tau Isoforms
por: Verelst, Joke, et al.
Publicado: (2020)

Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
por: Sottejeau, Yoann, et al.
Publicado: (2015)

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A(2A) receptor
por: Carvalho, Kevin, et al.
Publicado: (2019)

From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy
por: Colin, Morvane, et al.
Publicado: (2019)

A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditions
por: Violet, Marie, et al.
Publicado: (2014)

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes
por: Rose, Kevin, et al.
Publicado: (2023)

Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
por: Zheng, Jin, et al.
Publicado: (2020)

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration
por: Tautou, Marie, et al.
Publicado: (2021)

EuroTau: towing scientists to tau without tautology
por: Mudher, Amrit, et al.
Publicado: (2017)

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model
por: Benderradji, Hamza, et al.
Publicado: (2022)

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
por: Kundel, Franziska, et al.
Publicado: (2018)

Encephalopathy induced by Alzheimer brain inoculation in a non-human primate
por: Gary, Charlotte, et al.
Publicado: (2019)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

In search of the Higgs boson: H -> tau tau
por: Cortada, Xavier
Publicado: (2013)

Tau deletion promotes brain insulin resistance
por: Marciniak, Elodie, et al.
Publicado: (2017)

Tau Stabilizes Chromatin Compaction
por: Rico, Thomas, et al.
Publicado: (2021)

MicroRNAs and the Regulation of Tau Metabolism
por: Hébert, Sébastien S., et al.
Publicado: (2012)

Dynamic interactions and Ca(2+)-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
por: Moreira, Guilherme G., et al.
Publicado: (2021)

AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation
por: Marinangeli, Claudia, et al.
Publicado: (2018)

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors
por: Despres, Clément, et al.
Publicado: (2019)

AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo
por: Domise, Manon, et al.
Publicado: (2016)

Detrimental Effects of Diet-Induced Obesity on τ Pathology Are Independent of Insulin Resistance in τ Transgenic Mice
por: Leboucher, Antoine, et al.
Publicado: (2013)

Hexameric Aggregation Nucleation Core Sequences and Diversity of Pathogenic Tau Strains
por: Wu, Ling, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_46m6i25nc8c0jue8mapknntlak