The establishment of CDK9/RNA PolII/H3K4me3/DNA methylation feedback promotes HOTAIR expression by RNA elongation enhancement in cancer

Long non-coding RNA HOX Transcript Antisense RNA (HOTAIR) is overexpressed in multiple cancers with diverse genetic profiles. Importantly, since HOTAIR heavily contributes to cancer progression by promoting tumor growth and metastasis, HOTAIR becomes a potential target for cancer therapy. However, t...

Descripción completa

Detalles Bibliográficos
Autores principales: Wong, Chi Hin, Li, Chi Han, Man Tong, Joanna Hung, Zheng, Duo, He, Qifang, Luo, Zhiyuan, Lou, Ut Kei, Wang, Jiatong, To, Ka-Fai, Chen, Yangchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077372/
https://www.ncbi.nlm.nih.gov/pubmed/35121112
http://dx.doi.org/10.1016/j.ymthe.2022.01.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077372/
https://www.ncbi.nlm.nih.gov/pubmed/35121112
http://dx.doi.org/10.1016/j.ymthe.2022.01.038

Ejemplares similares