Colon-targeting mutual prodrugs of 5-aminosalicylic acid and butyrate for the treatment of ulcerative colitis

The aim of this study was to design and synthesize four colon-targeting mutual prodrugs of 5-aminosalicylic acid (5-ASA) and butyrate, and evaluate their therapeutic effects on ulcerative colitis. Herein, 5-ASB, 5-ASDB, Ols-DB and Ols-DBP were prepared and characterized, and their lipophilicity, sol...

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Detalles Bibliográficos
Autores principales: Yan, Yan, Sun, Jinyao, Xie, Xianting, Wang, Pengchong, Sun, Ying, Dong, Yalin, Xing, Jianfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077470/
https://www.ncbi.nlm.nih.gov/pubmed/35541446
http://dx.doi.org/10.1039/c7ra13011b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077470/
https://www.ncbi.nlm.nih.gov/pubmed/35541446
http://dx.doi.org/10.1039/c7ra13011b

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