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Colon-targeting mutual prodrugs of 5-aminosalicylic acid and butyrate for the treatment of ulcerative colitis

The aim of this study was to design and synthesize four colon-targeting mutual prodrugs of 5-aminosalicylic acid (5-ASA) and butyrate, and evaluate their therapeutic effects on ulcerative colitis. Herein, 5-ASB, 5-ASDB, Ols-DB and Ols-DBP were prepared and characterized, and their lipophilicity, sol...

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Detalles Bibliográficos
Autores principales:	Yan, Yan, Sun, Jinyao, Xie, Xianting, Wang, Pengchong, Sun, Ying, Dong, Yalin, Xing, Jianfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077470/ https://www.ncbi.nlm.nih.gov/pubmed/35541446 http://dx.doi.org/10.1039/c7ra13011b

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