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Synthesis of C14–C21 acid fragments of cytochalasin Z(8)via anti-selective aldol condensation and B-alkyl Suzuki–Miyaura cross-coupling
An efficient synthesis of the C14–C21 acid fragment of cytochalasin Z(8) was accomplished in 10 steps with 14% overall yield. Boron-mediated anti-selective aldol condensation and Pd(OAc)(2)–Aphos-Y-catalysed B-alkyl Suzuki–Miyaura cross-coupling were employed to construct the requisite C17 and C18 s...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Royal Society of Chemistry
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9077782/ https://www.ncbi.nlm.nih.gov/pubmed/35542899 http://dx.doi.org/10.1039/c7ra13391j |