An imidazole modified lipid confers enhanced mRNA-LNP stability and strong immunization properties in mice and non-human primates

The mRNA vaccine technology has promising applications to fight infectious diseases as demonstrated by the licensing of two mRNA-based vaccines, Comirnaty® (Pfizer/BioNtech) and Spikevax® (Moderna), in the context of the Covid-19 crisis. Safe and effective delivery systems are essential to the perfo...

Descripción completa

Detalles Bibliográficos
Autores principales: Ripoll, Manon, Bernard, Marie-Clotilde, Vaure, Céline, Bazin, Emilie, Commandeur, Sylvie, Perkov, Vladimir, Lemdani, Katia, Nicolaï, Marie-Claire, Bonifassi, Patrick, Kichler, Antoine, Frisch, Benoit, Haensler, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078044/
https://www.ncbi.nlm.nih.gov/pubmed/35576809
http://dx.doi.org/10.1016/j.biomaterials.2022.121570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078044/
https://www.ncbi.nlm.nih.gov/pubmed/35576809
http://dx.doi.org/10.1016/j.biomaterials.2022.121570

Ejemplares similares