Cargando…

An efficient and scalable synthesis of potent TLR2 agonistic PAM(2)CSK(4)

Diacylated PAM(2)CSK(4), a highly expensive lipopeptide with desirable aqueous solubility and a broad spectrum of cytokine/chemokine induction is a most potent dual (human and murine) Toll-Like Receptor-2 (TLR2) agonist. Besides such thrilling characteristics, its synthetic process is not reported i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaur, Arshpreet, Poonam, Patil, Madhuri T., Mehta, Surinder K., Salunke, Deepak B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078680/ https://www.ncbi.nlm.nih.gov/pubmed/35540846 http://dx.doi.org/10.1039/c8ra01387j

Ejemplares similares

Coinjection with TLR2 Agonist Pam3CSK4 Reduces the Pathology of Leishmanization in Mice
por: Huang, Lu, et al.
Publicado: (2015)

Molecular Dynamics Studies of Poly(Lactic Acid) Nanoparticles and Their Interactions with Vitamin E and TLR Agonists Pam(1)CSK(4) and Pam(3)CSK(4)
por: Megy, Simon, et al.
Publicado: (2020)

Control of Methicillin-Resistant Staphylococcus aureus Pneumonia Utilizing TLR2 Agonist Pam3CSK4
por: Chen, Yi-Guo, et al.
Publicado: (2016)

The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation
por: Nguyen, D. Tien, et al.
Publicado: (2010)

The inflammatory cytokine effect of Pam3CSK4 TLR2 agonist alone or in combination with Leishmania infantum antigen on ex-vivo whole blood from sick and resistant dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2017)

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models
por: Halliday, Alice, et al.
Publicado: (2016)

Potent Adjuvanticity of a Pure TLR7-Agonistic Imidazoquinoline Dendrimer
por: Shukla, Nikunj M., et al.
Publicado: (2012)

Yb(OTf)(3)-Catalyzed and Di-tert-butyl Dicarbonate-Mediated Decarboxylative Etherification and Esterification Reactions
por: Kaur, Arshpreet, et al.
Publicado: (2020)

Differential Effects of the Toll-Like Receptor 2 Agonists, PGN and Pam3CSK4 on Anti-IgE Induced Human Mast Cell Activation
por: Yu, Yangyang, et al.
Publicado: (2014)

Effects of the TLR2 Agonists MALP-2 and Pam(3)Cys in Isolated Mouse Lungs
por: Barrenschee, Martina, et al.
Publicado: (2010)

Siegesbeckia pubescens Makino inhibits Pam(3)CSK(4)-induced inflammation in RAW 264.7 macrophages through suppressing TLR1/TLR2-mediated NF-κB activation
por: Sang, Wei, et al.
Publicado: (2018)

TLR2 Ligand Pam3CSK4 Regulates MMP-2/9 Expression by MAPK/NF-κB Signaling Pathways in Primary Brain Microvascular Endothelial Cells
por: Zhu, Hongyan, et al.
Publicado: (2018)

A20 Is Critical for the Induction of Pam3CSK4-Tolerance in Monocytic THP-1 Cells
por: Hu, Jinyue, et al.
Publicado: (2014)

BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant
por: Kaushik, Deepender, et al.
Publicado: (2020)

Pam2CSK4-adjuvanted SARS-CoV-2 RBD nanoparticle vaccine induces robust humoral and cellular immune responses
por: Qiao, Yidan, et al.
Publicado: (2022)

Toll-like Receptor 1/2 Agonist Pam3CSK4 Suppresses Lipopolysaccharide-driven IgG1 Production while Enhancing IgG2a Production by B Cells
por: Lee, Sang-Hoon, et al.
Publicado: (2018)

Generation of Adaptive Immune Responses Following Influenza Virus Challenge is Not Compromised by Pre-Treatment with the TLR-2 Agonist Pam(2)Cys
por: Mifsud, Edin Jessica, et al.
Publicado: (2015)

Adjuvant Pam3CSk4 does not improve the immunization against Cryptococcus gattii infection in C57BL/6 mice
por: de Campos, Gabriela Yamazaki, et al.
Publicado: (2023)

Combination of poly I:C and Pam3CSK4 enhances activation of B cells in vitro and boosts antibody responses to protein vaccines in vivo
por: Weir, Genevieve M., et al.
Publicado: (2017)

Xuebijing Injection Alleviates Pam3CSK4-Induced Inflammatory Response and Protects Mice From Sepsis Caused by Methicillin-Resistant Staphylococcus aureus
por: Li, Tiantian, et al.
Publicado: (2020)

The Toll-Like Receptor 2 Ligand Pam2CSK4 Activates Platelet Nuclear Factor-κB and Bruton’s Tyrosine Kinase Signaling to Promote Platelet-Endothelial Cell Interactions
por: Parra-Izquierdo, Iván, et al.
Publicado: (2021)

Evaluation of different combination of pam2CSK4, poly (I:C) and imiquimod enhance immune responses to H9N2 avian influenza antigen in dendritic cells and duck
por: Zhang, Aiguo, et al.
Publicado: (2022)

Regulation, targets and functions of CSK
por: Zhu, Shudong, et al.
Publicado: (2023)

Covalently Conjugated NOD2/TLR7 Agonists Are Potent and Versatile Immune Potentiators
por: Guzelj, Samo, et al.
Publicado: (2022)

Regulation of the Src Family Kinases by Csk
por: Okada, Masato
Publicado: (2012)

CSK-mediated signalling by integrins in cancer
por: Maldonado, Horacio, et al.
Publicado: (2023)

Editorial: Regulation and dysfunction of CSK and CHK
por: Zhu, Shudong, et al.
Publicado: (2023)

Pro-inflammatory response ensured by LPS and Pam3CSK4 in RAW 264.7 cells did not improve a fungistatic effect on Cryptococcus gattii infection
por: de Campos, Gabriela Yamazaki, et al.
Publicado: (2020)

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists
por: Zhou, Yang, et al.
Publicado: (2019)

A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
por: Tawaratsumida, Kazuki, et al.
Publicado: (2022)

Mitotic Activation of c‐Src Is Suppressed by Csk
por: Ohsato, Yoshiharu, et al.
Publicado: (1994)

Apoptosis regulation by the tyrosine-protein kinase CSK
por: Fortner, Andra, et al.
Publicado: (2022)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
por: Sun, Jinghua, et al.
Publicado: (2012)

New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses
por: Gutjahr, Alice, et al.
Publicado: (2020)

Design and Structural Requirements of the Potent and Safe TLR-9 Agonistic Immunomodulator MGN1703
por: Schmidt, Manuel, et al.
Publicado: (2015)

Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure
por: Lee, Hyeon-Ju, et al.
Publicado: (2016)

Design and Immunological Evaluation of a Hybrid Peptide as a Potent TLR2 Agonist by Structure-Based Virtual Screening
por: Zhang, Lulu, et al.
Publicado: (2021)

Nucleic acid ligands act as a PAM and agonist depending on the intrinsic ligand binding state of P2RY2
por: Takahashi, Masaki, et al.
Publicado: (2021)

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
por: Cheng, Kui, et al.
Publicado: (2015)

LYP inhibits T cell activation when dissociated from CSK
por: Vang, Torkel, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d746ihs8mq3cmst01osf6oa4o5