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Efficient biocatalytic stereoselective reduction of methyl acetoacetate catalyzed by whole cells of engineered E. coli

Asymmetric synthesis of chiral β-hydroxy esters, the key building blocks for many functional materials, is currently of great interest. In this study, the biocatalytic anti-Prelog reduction of methyl acetoacetate (MAA) to methyl-(R)-3-hydroxybutyrate ((R)-HBME) was successfully carried out with high...

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Detalles Bibliográficos
Autores principales: Cui, Y. H., Wei, P., Peng, F., Zong, M. H., Lou, W. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078740/
https://www.ncbi.nlm.nih.gov/pubmed/35540821
http://dx.doi.org/10.1039/c8ra00883c