Identification of a new series of benzothiazinone derivatives with excellent antitubercular activity and improved pharmacokinetic profiles

Nitrobenzothiazinone (BTZ) is a promising scaffold with potent activity against M. tuberculosis by inhibiting decaprenylphosphoryl-beta-d-ribose 2′-oxidase (DprE1). But unfavorable durability poses a challenge to further development of this class of agents. Herein, a series of BTZs bearing a variety...

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Detalles Bibliográficos
Autores principales: Xiong, Lu, Gao, Chao, Shi, Yao-Jie, Tao, Xin, Rong, Juan, Liu, Kun-Lin, Peng, Cui-Ting, Wang, Ning-Yu, Lei, Qian, Zhang, Yi-Wen, Yu, Luo-Ting, Wei, Yu-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078972/
https://www.ncbi.nlm.nih.gov/pubmed/35541526
http://dx.doi.org/10.1039/c8ra00720a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078972/
https://www.ncbi.nlm.nih.gov/pubmed/35541526
http://dx.doi.org/10.1039/c8ra00720a

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