Formal total synthesis of histrionicotoxin alkaloids via Hg(OTf)(2)-catalyzed cycloisomerization and SmI(2)-induced ring expansion

The efficient formal total synthesis of histrionicotoxin alkaloids was achieved. In this process, two key reactions were used to construct a core 1-azaspiro[5.5]undecane framework common to histrionicotoxins: a mercuric triflate (Hg(OTf)(2))-catalyzed cycloisomerization of a linear substrate, which...

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Detalles Bibliográficos
Autores principales: Matsumura, Kunihiro, Nishikawa, Keisuke, Yoshida, Hiroaki, Doe, Matsumi, Morimoto, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079123/
https://www.ncbi.nlm.nih.gov/pubmed/35542821
http://dx.doi.org/10.1039/c8ra02011f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079123/
https://www.ncbi.nlm.nih.gov/pubmed/35542821
http://dx.doi.org/10.1039/c8ra02011f

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