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Formal total synthesis of histrionicotoxin alkaloids via Hg(OTf)(2)-catalyzed cycloisomerization and SmI(2)-induced ring expansion
The efficient formal total synthesis of histrionicotoxin alkaloids was achieved. In this process, two key reactions were used to construct a core 1-azaspiro[5.5]undecane framework common to histrionicotoxins: a mercuric triflate (Hg(OTf)(2))-catalyzed cycloisomerization of a linear substrate, which...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079123/ https://www.ncbi.nlm.nih.gov/pubmed/35542821 http://dx.doi.org/10.1039/c8ra02011f |