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Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition

The imbalance of bone homeostasis is the root cause of osteoporosis. However current therapeutic approaches mainly focus on either anabolic or catabolic pathways, which often fail to turn the imbalanced bone metabolism around. Herein we reported that a SIRT-1 agonist mediated molecular therapeutic s...

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Detalles Bibliográficos
Autores principales: Zhang, Wei, Zhou, Xingzhi, Hou, Weiduo, Chen, Erman, Ye, Chenyi, Chen, Mo, Lu, Qian, Yu, Xiaohua, Li, Weixu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079176/
https://www.ncbi.nlm.nih.gov/pubmed/35574058
http://dx.doi.org/10.1016/j.bioactmat.2022.04.017