The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

Parkinson’s disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as the accumulation of intraneuronal proteinaceous inclusions known as Lewy bodies and Lewy neurites. The major protein component of Lewy inclusions is the intrinsic...

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Detalles Bibliográficos
Autores principales: Peña-Díaz, Samuel, Pujols, Jordi, Vasili, Eftychia, Pinheiro, Francisca, Santos, Jaime, Manglano-Artuñedo, Zoe, Outeiro, Tiago F., Ventura, Salvador
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079179/
https://www.ncbi.nlm.nih.gov/pubmed/35390347
http://dx.doi.org/10.1016/j.jbc.2022.101902

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079179/
https://www.ncbi.nlm.nih.gov/pubmed/35390347
http://dx.doi.org/10.1016/j.jbc.2022.101902

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