Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity

Bordetella pertussis is the causative agent of whooping cough, a highly contagious respiratory disease. Pertussis toxin (PT), a major virulence factor secreted by B. pertussis, is an AB5-type protein complex topologically related to cholera toxin. The PT protein complex is internalized by host cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Sakari, Moona, Tran, Mai T., Rossjohn, Jamie, Pulliainen, Arto T., Beddoe, Travis, Littler, Dene R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079181/
https://www.ncbi.nlm.nih.gov/pubmed/35378130
http://dx.doi.org/10.1016/j.jbc.2022.101892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079181/
https://www.ncbi.nlm.nih.gov/pubmed/35378130
http://dx.doi.org/10.1016/j.jbc.2022.101892

Ejemplares similares