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Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity

Bordetella pertussis is the causative agent of whooping cough, a highly contagious respiratory disease. Pertussis toxin (PT), a major virulence factor secreted by B. pertussis, is an AB5-type protein complex topologically related to cholera toxin. The PT protein complex is internalized by host cells...

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Detalles Bibliográficos
Autores principales:	Sakari, Moona, Tran, Mai T., Rossjohn, Jamie, Pulliainen, Arto T., Beddoe, Travis, Littler, Dene R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079181/ https://www.ncbi.nlm.nih.gov/pubmed/35378130 http://dx.doi.org/10.1016/j.jbc.2022.101892

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