Computer-aided drug design, synthesis and identification of disulfide compounds as novel and potential allosteric PAK1 inhibitors

p21-activated kinase 1 (PAK1) is an evolutionarily conserved serine/threonine protein kinase, which has been considered as one of the key regulatory factors in signaling network of tumor cells. Therefore, inhibition of PAK1 may be a potential approach to treat many types of solid tumors. Several all...

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Detalles Bibliográficos
Autores principales: Huang, Hanwei, Jiang, Hailun, Zhang, Xiangyu, Li, Wei, Wang, Pengliang, Liu, Funan, Wang, Jian, Bai, Mingfeng, Cheng, Maosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079282/
https://www.ncbi.nlm.nih.gov/pubmed/35539390
http://dx.doi.org/10.1039/c8ra00621k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079282/
https://www.ncbi.nlm.nih.gov/pubmed/35539390
http://dx.doi.org/10.1039/c8ra00621k

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