Rational design of a new cytarabine-based prodrug for highly efficient oral delivery of cytarabine

Because of the drawbacks of cytarabine (Ara-C) such as poor lipid solubility, deamination inactivation and low oral bioavailability limiting its application by oral administration, herein we propose a novel amphiphilic low molecular weight cytarabine prodrug (PA-Ara) by conjugating palmitic acid (PA...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, Zhang, Di, Hu, Xu, Liu, Ruiling, Li, Zhonghao, Luan, Yuxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079750/
https://www.ncbi.nlm.nih.gov/pubmed/35542498
http://dx.doi.org/10.1039/c8ra01225c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079750/
https://www.ncbi.nlm.nih.gov/pubmed/35542498
http://dx.doi.org/10.1039/c8ra01225c

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