A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A

Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The s...

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Detalles Bibliográficos
Autores principales: Xu, Jingjing, Wang, Kai, Wu, Jinlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079787/
https://www.ncbi.nlm.nih.gov/pubmed/35539328
http://dx.doi.org/10.1039/c8ra02052c
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author Xu, Jingjing
Wang, Kai
Wu, Jinlong
author_facet Xu, Jingjing
Wang, Kai
Wu, Jinlong
author_sort Xu, Jingjing
collection PubMed
description Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities.
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spelling pubmed-90797872022-05-09 A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A Xu, Jingjing Wang, Kai Wu, Jinlong RSC Adv Chemistry Psammaplysene A, an inhibitor of FOXO1a-mediated nuclear export, has been synthesized by a concise and improved route from tyrosine-derived acid and amine fragments which were easily constructed using commercially available p-hydroxybenzaldehyde and tyramine as starting material, respectively. The strategy provides an efficient access of psammaplysene analogues that can be explored for potential pharmaceutical or biological activities. The Royal Society of Chemistry 2018-04-12 /pmc/articles/PMC9079787/ /pubmed/35539328 http://dx.doi.org/10.1039/c8ra02052c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Xu, Jingjing
Wang, Kai
Wu, Jinlong
A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title_full A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title_fullStr A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title_full_unstemmed A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title_short A short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene A
title_sort short and efficient total synthesis of the bromotyrosine-derived alkaloid psammaplysene a
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079787/
https://www.ncbi.nlm.nih.gov/pubmed/35539328
http://dx.doi.org/10.1039/c8ra02052c
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AT wangkai ashortandefficienttotalsynthesisofthebromotyrosinederivedalkaloidpsammaplysenea
AT wujinlong ashortandefficienttotalsynthesisofthebromotyrosinederivedalkaloidpsammaplysenea
AT xujingjing shortandefficienttotalsynthesisofthebromotyrosinederivedalkaloidpsammaplysenea
AT wangkai shortandefficienttotalsynthesisofthebromotyrosinederivedalkaloidpsammaplysenea
AT wujinlong shortandefficienttotalsynthesisofthebromotyrosinederivedalkaloidpsammaplysenea

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