Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones

A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for th...

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Autores principales: Hu, Quan-Fang, Gao, Tian-Tao, Shi, Yao-Jie, Lei, Qian, Yu, Luo-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079793/
https://www.ncbi.nlm.nih.gov/pubmed/35539333
http://dx.doi.org/10.1039/c8ra02099j
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author Hu, Quan-Fang
Gao, Tian-Tao
Shi, Yao-Jie
Lei, Qian
Yu, Luo-Ting
author_facet Hu, Quan-Fang
Gao, Tian-Tao
Shi, Yao-Jie
Lei, Qian
Yu, Luo-Ting
author_sort Hu, Quan-Fang
collection PubMed
description A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o-chlorobenzamides.
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spelling pubmed-90797932022-05-09 Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones Hu, Quan-Fang Gao, Tian-Tao Shi, Yao-Jie Lei, Qian Yu, Luo-Ting RSC Adv Chemistry A palladium catalyzed synthesis of N–H phenanthridinones was developed via C–H arylation. The protocol gives phenanthridinones regioselectively by one-pot reaction without deprotection. It exhibits broad substrate scope and affords targets in up to 95% yields. Importantly, it could be applied for the less reactive o-chlorobenzamides. The Royal Society of Chemistry 2018-04-13 /pmc/articles/PMC9079793/ /pubmed/35539333 http://dx.doi.org/10.1039/c8ra02099j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Hu, Quan-Fang
Gao, Tian-Tao
Shi, Yao-Jie
Lei, Qian
Yu, Luo-Ting
Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title_full Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title_fullStr Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title_full_unstemmed Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title_short Palladium-catalyzed intramolecular C–H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N–H phenanthridinones
title_sort palladium-catalyzed intramolecular c–h arylation of 2-halo-n-boc-n-arylbenzamides for the synthesis of n–h phenanthridinones
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079793/
https://www.ncbi.nlm.nih.gov/pubmed/35539333
http://dx.doi.org/10.1039/c8ra02099j
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