Trifluoromethylated proline analogues as efficient tools to enhance the hydrophobicity and to promote passive diffusion transport of the l-prolyl-l-leucyl glycinamide (PLG) tripeptide

The synthesis of four CF(3)-proline analogues of the PLG peptide is reported. Our results show that the incorporation of trifluoromethylated amino acids (Tfm-AAs) at the N-terminal position of a peptide significantly increases its hydrophobicity. In addition, depending on the relative configuration...

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Detalles Bibliográficos
Autores principales: Oliver, Martin, Gadais, Charlène, García-Pindado, Júlia, Teixidó, Meritxell, Lensen, Nathalie, Chaume, Grégory, Brigaud, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079923/
https://www.ncbi.nlm.nih.gov/pubmed/35540789
http://dx.doi.org/10.1039/c8ra02511h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079923/
https://www.ncbi.nlm.nih.gov/pubmed/35540789
http://dx.doi.org/10.1039/c8ra02511h

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