One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis

A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF(3)SO(3)H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF(3)CH(2)OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibi...

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Autores principales: Liu, Huan, Liu, Sensheng, Zhou, Haifeng, Liu, Qixing, Wang, Chunqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079948/
https://www.ncbi.nlm.nih.gov/pubmed/35541341
http://dx.doi.org/10.1039/c8ra02224k
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author Liu, Huan
Liu, Sensheng
Zhou, Haifeng
Liu, Qixing
Wang, Chunqin
author_facet Liu, Huan
Liu, Sensheng
Zhou, Haifeng
Liu, Qixing
Wang, Chunqin
author_sort Liu, Huan
collection PubMed
description A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF(3)SO(3)H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF(3)CH(2)OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions.
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spelling pubmed-90799482022-05-09 One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis Liu, Huan Liu, Sensheng Zhou, Haifeng Liu, Qixing Wang, Chunqin RSC Adv Chemistry A practical one-pot synthesis of chiral alcohols from readily available alkynes via tandem catalysis by the combination of CF(3)SO(3)H and a fluorinated chiral diamine Ru(ii) complex in aqueous CF(3)CH(2)OH is described. Very interestingly, the combination of fluorinated catalysts and solvent exhibits a positive fluorine effect on the reactivity and enantioselectivity. A range of chiral alcohols with wide functional group tolerance was obtained in high yield and excellent stereoselectivity under simple and mild conditions. The Royal Society of Chemistry 2018-04-19 /pmc/articles/PMC9079948/ /pubmed/35541341 http://dx.doi.org/10.1039/c8ra02224k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Liu, Huan
Liu, Sensheng
Zhou, Haifeng
Liu, Qixing
Wang, Chunqin
One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title_full One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title_fullStr One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title_full_unstemmed One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title_short One-pot synthesis of chiral alcohols from alkynes by CF(3)SO(3)H/ruthenium tandem catalysis
title_sort one-pot synthesis of chiral alcohols from alkynes by cf(3)so(3)h/ruthenium tandem catalysis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079948/
https://www.ncbi.nlm.nih.gov/pubmed/35541341
http://dx.doi.org/10.1039/c8ra02224k
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