Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1

Spirooxindole is a promising chemo therapeutic agent. Possible targets include cancers of the liver, prostate, lung, stomach, colon, and breast. Here, we demonstrate a one-pot three-component reaction via a [3 + 2] cycloaddition/ring contraction sequence of a dipolarophile (activated alkene) with in...

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Detalles Bibliográficos
Autores principales: Barakat, Assem, Islam, Mohammad Shahidul, Ghawas, Hussien Mansur, Al-Majid, Abdullah Mohammed, El-Senduny, Fardous F., Badria, Farid A., Elshaier, Yaseen A. M. M., Ghabbour, Hazem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079959/
https://www.ncbi.nlm.nih.gov/pubmed/35540737
http://dx.doi.org/10.1039/c8ra02358a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9079959/
https://www.ncbi.nlm.nih.gov/pubmed/35540737
http://dx.doi.org/10.1039/c8ra02358a

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