A C(1)-symmetric N-heterocyclic carbene catalysed oxidative spiroannulation of isatin-derived enals: highly enantioselective synthesis of spirooxindole δ-lactones

A C(1)-symmetric N-heterocyclic carbene (NHC)-catalysed activation of isatin-derived enals under oxidative conditions was achieved. The in situ generated α,β-unsaturated acyl azolium species was efficiently trapped by 1,3-dicarbonyl compounds via a Michael addition/spiroannualtion cascade, deliverin...

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Detalles Bibliográficos
Autores principales: Lin, Jun-Bing, Cheng, Xi-Na, Tian, Xiao-Dong, Xu, Guo-Qiang, Luo, Yong-Chun, Xu, Peng-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080099/
https://www.ncbi.nlm.nih.gov/pubmed/35539478
http://dx.doi.org/10.1039/c8ra02009d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080099/
https://www.ncbi.nlm.nih.gov/pubmed/35539478
http://dx.doi.org/10.1039/c8ra02009d

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