The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT(6) receptor antagonists and beyond

The development of compounds with enhanced activity and selectivity by a conserved spatial orientation of the pharmacophore elements has a long history in medicinal chemistry. Rigidified compounds are an example of this concept. However, the intramolecular interactions were seldom used as a basis fo...

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Detalles Bibliográficos
Autores principales: Kalinowska-Tłuścik, Justyna, Staroń, Jakub, Krawczuk, Anna, Mordalski, Stefan, Warszycki, Dawid, Satała, Grzegorz, Hogendorf, Adam S., Bojarski, Andrzej J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080534/
https://www.ncbi.nlm.nih.gov/pubmed/35541096
http://dx.doi.org/10.1039/c8ra03107j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080534/
https://www.ncbi.nlm.nih.gov/pubmed/35541096
http://dx.doi.org/10.1039/c8ra03107j

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