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The effect of the intramolecular C–H⋯O interactions on the conformational preferences of bis-arylsulfones – 5-HT(6) receptor antagonists and beyond
The development of compounds with enhanced activity and selectivity by a conserved spatial orientation of the pharmacophore elements has a long history in medicinal chemistry. Rigidified compounds are an example of this concept. However, the intramolecular interactions were seldom used as a basis fo...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080534/ https://www.ncbi.nlm.nih.gov/pubmed/35541096 http://dx.doi.org/10.1039/c8ra03107j |