Compound F779-0434 causes synthetic lethality in BRCA2-deficient cancer cells by disrupting RAD52–ssDNA association

Maintenance of genomic integrity is essential for the survival of all organisms. Homologous recombination (HR) is the major pathway for high-fidelity repair of DNA double-stranded breaks (DSBs). In addition to the classic BRCA–RAD51 pathway, another secondary HR sub-pathway dependent on RAD52 has be...

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Detalles Bibliográficos
Autores principales: Li, Jian, Yang, Qianye, Zhang, Yang, Huang, Kejia, Sun, Rong, Zhao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080615/
https://www.ncbi.nlm.nih.gov/pubmed/35539677
http://dx.doi.org/10.1039/c8ra01919c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080615/
https://www.ncbi.nlm.nih.gov/pubmed/35539677
http://dx.doi.org/10.1039/c8ra01919c

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