Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex

We herein report the development of a convenient, regioselective, aromatic fluorination method of hypervalent iodonium ylides for synthesising fluoro-arenes on a preparative scale. This transition metal free, nucleophilic methodology provides good yields for sterically hindered substrates, irrespect...

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Detalles Bibliográficos
Autores principales: Jakobsson, Jimmy Erik, Riss, Patrick Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080924/
https://www.ncbi.nlm.nih.gov/pubmed/35539958
http://dx.doi.org/10.1039/c8ra03757d
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author Jakobsson, Jimmy Erik
Riss, Patrick Johannes
author_facet Jakobsson, Jimmy Erik
Riss, Patrick Johannes
author_sort Jakobsson, Jimmy Erik
collection PubMed
description We herein report the development of a convenient, regioselective, aromatic fluorination method of hypervalent iodonium ylides for synthesising fluoro-arenes on a preparative scale. This transition metal free, nucleophilic methodology provides good yields for sterically hindered substrates, irrespective of activation. The methodology simplifies reference synthesis for PET imaging.
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spelling pubmed-90809242022-05-09 Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex Jakobsson, Jimmy Erik Riss, Patrick Johannes RSC Adv Chemistry We herein report the development of a convenient, regioselective, aromatic fluorination method of hypervalent iodonium ylides for synthesising fluoro-arenes on a preparative scale. This transition metal free, nucleophilic methodology provides good yields for sterically hindered substrates, irrespective of activation. The methodology simplifies reference synthesis for PET imaging. The Royal Society of Chemistry 2018-06-11 /pmc/articles/PMC9080924/ /pubmed/35539958 http://dx.doi.org/10.1039/c8ra03757d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Jakobsson, Jimmy Erik
Riss, Patrick Johannes
Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title_full Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title_fullStr Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title_full_unstemmed Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title_short Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex
title_sort transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a kf/crypt-222 complex
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9080924/
https://www.ncbi.nlm.nih.gov/pubmed/35539958
http://dx.doi.org/10.1039/c8ra03757d
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