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Stapling strategy enables improvement of antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B
Hymenochirin-1B is a cationic, amphipathic, α-helical host-defense peptide with 29 residues, which was isolated from skin secretions of the Congo clawed frog and showed potent cytotoxic activities against a range of tumor cell lines. However, the application of hymenochirin-1B as a drug is limited d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081086/ https://www.ncbi.nlm.nih.gov/pubmed/35541711 http://dx.doi.org/10.1039/c8ra03446j |