Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here, we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. Following spinal cord injury, CSF-bor...

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Autores principales: Mazzitelli, Jose A., Smyth, Leon C.D., Cross, Kevin A., Dykstra, Taitea, Sun, Jerry, Du, Siling, Mamuladze, Tornike, Smirnov, Igor, Rustenhoven, Justin, Kipnis, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081158/
https://www.ncbi.nlm.nih.gov/pubmed/35301477
http://dx.doi.org/10.1038/s41593-022-01029-1
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author Mazzitelli, Jose A.
Smyth, Leon C.D.
Cross, Kevin A.
Dykstra, Taitea
Sun, Jerry
Du, Siling
Mamuladze, Tornike
Smirnov, Igor
Rustenhoven, Justin
Kipnis, Jonathan
author_facet Mazzitelli, Jose A.
Smyth, Leon C.D.
Cross, Kevin A.
Dykstra, Taitea
Sun, Jerry
Du, Siling
Mamuladze, Tornike
Smirnov, Igor
Rustenhoven, Justin
Kipnis, Jonathan
author_sort Mazzitelli, Jose A.
collection PubMed
description It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here, we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. Following spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS- and CSF-to-bone-marrow communication that regulates CNS immune responses.
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spelling pubmed-90811582022-09-17 Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels Mazzitelli, Jose A. Smyth, Leon C.D. Cross, Kevin A. Dykstra, Taitea Sun, Jerry Du, Siling Mamuladze, Tornike Smirnov, Igor Rustenhoven, Justin Kipnis, Jonathan Nat Neurosci Article It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here, we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. Following spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS- and CSF-to-bone-marrow communication that regulates CNS immune responses. 2022-05 2022-03-17 /pmc/articles/PMC9081158/ /pubmed/35301477 http://dx.doi.org/10.1038/s41593-022-01029-1 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Mazzitelli, Jose A.
Smyth, Leon C.D.
Cross, Kevin A.
Dykstra, Taitea
Sun, Jerry
Du, Siling
Mamuladze, Tornike
Smirnov, Igor
Rustenhoven, Justin
Kipnis, Jonathan
Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title_full Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title_fullStr Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title_full_unstemmed Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title_short Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
title_sort cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081158/
https://www.ncbi.nlm.nih.gov/pubmed/35301477
http://dx.doi.org/10.1038/s41593-022-01029-1
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