Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom subs...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoshida, Suguru, Kuribara, Tomoko, Morita, Takamoto, Matsuzawa, Tsubasa, Morimoto, Kazushi, Kobayashi, Takuya, Hosoya, Takamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081209/
https://www.ncbi.nlm.nih.gov/pubmed/35541723
http://dx.doi.org/10.1039/c8ra04035d
Descripción
Sumario:Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom substituents, and can be applied to the synthesis of EP4 antagonist analogs.

Ejemplares similares