Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors

Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom subs...

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Detalles Bibliográficos
Autores principales: Yoshida, Suguru, Kuribara, Tomoko, Morita, Takamoto, Matsuzawa, Tsubasa, Morimoto, Kazushi, Kobayashi, Takuya, Hosoya, Takamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081209/
https://www.ncbi.nlm.nih.gov/pubmed/35541723
http://dx.doi.org/10.1039/c8ra04035d
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author Yoshida, Suguru
Kuribara, Tomoko
Morita, Takamoto
Matsuzawa, Tsubasa
Morimoto, Kazushi
Kobayashi, Takuya
Hosoya, Takamitsu
author_facet Yoshida, Suguru
Kuribara, Tomoko
Morita, Takamoto
Matsuzawa, Tsubasa
Morimoto, Kazushi
Kobayashi, Takuya
Hosoya, Takamitsu
author_sort Yoshida, Suguru
collection PubMed
description Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom substituents, and can be applied to the synthesis of EP4 antagonist analogs.
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spelling pubmed-90812092022-05-09 Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors Yoshida, Suguru Kuribara, Tomoko Morita, Takamoto Matsuzawa, Tsubasa Morimoto, Kazushi Kobayashi, Takuya Hosoya, Takamitsu RSC Adv Chemistry Various 2,3-disubstituted 6,7-thienobenzynes have been efficiently generated from the corresponding o-silylaryl triflate-type precursors by activation with fluoride ions. The method has expanded the scope of synthesizable multisubstituted benzothiophenes, including those with various heteroatom substituents, and can be applied to the synthesis of EP4 antagonist analogs. The Royal Society of Chemistry 2018-06-13 /pmc/articles/PMC9081209/ /pubmed/35541723 http://dx.doi.org/10.1039/c8ra04035d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Yoshida, Suguru
Kuribara, Tomoko
Morita, Takamoto
Matsuzawa, Tsubasa
Morimoto, Kazushi
Kobayashi, Takuya
Hosoya, Takamitsu
Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title_full Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title_fullStr Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title_full_unstemmed Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title_short Expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
title_sort expanding the synthesizable multisubstituted benzo[b]thiophenes via 6,7-thienobenzynes generated from o-silylaryl triflate-type precursors
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081209/
https://www.ncbi.nlm.nih.gov/pubmed/35541723
http://dx.doi.org/10.1039/c8ra04035d
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