Gut Microbial β-Glucuronidases Regulate Host Luminal Proteases and are depleted in Irritable Bowel Syndrome

Intestinal proteases mediate digestion and immune signaling, while increased gut proteolytic activity disrupts the intestinal barrier and generates visceral hypersensitivity, which in common in irritable bowel syndrome (IBS). However, the mechanisms controlling protease function are unclear. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Edwinson, Adam L., Yang, Lu, Peters, Stephanie, Hanning, Nikita, Jeraldo, Patricio, Jagtap, Pratik, Simpson, Joshua B., Yang, Tzu-Yi, Kumar, Praveen, Mehta, Subina, Nair, Asha, Breen-Lyles, Margaret, Chikkamenahalli, Lakshmikanth, Graham, Rondell P., De Winter, Benedicte, Patel, Robin, Dasari, Surendra, Kashyap, Purna, Griffin, Timothy, Chen, Jun, Farrugia, Gianrico, Redinbo, Matthew R., Grover, Madhusudan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081267/
https://www.ncbi.nlm.nih.gov/pubmed/35484230
http://dx.doi.org/10.1038/s41564-022-01103-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081267/
https://www.ncbi.nlm.nih.gov/pubmed/35484230
http://dx.doi.org/10.1038/s41564-022-01103-1

Ejemplares similares