Cargando…

FUCCI-Based Live Imaging Platform Reveals Cell Cycle Dynamics and Identifies Pro-proliferative Compounds in Human iPSC-Derived Cardiomyocytes

One of the major goals in cardiac regeneration research is to replace lost ventricular tissue with new cardiomyocytes. However, cardiomyocyte proliferation drops to low levels in neonatal hearts and is no longer efficient in compensating for the loss of functional myocardium in heart disease. We gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murganti, Francesca, Derks, Wouter, Baniol, Marion, Simonova, Irina, Trus, Palina, Neumann, Katrin, Khattak, Shahryar, Guan, Kaomei, Bergmann, Olaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081338/ https://www.ncbi.nlm.nih.gov/pubmed/35548410 http://dx.doi.org/10.3389/fcvm.2022.840147

Ejemplares similares

Cardiomyocyte renewal in the failing heart: lessons from the neonate?
por: Derks, Wouter, et al.
Publicado: (2020)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research
por: Patel, Leena, et al.
Publicado: (2023)

Transplantation of purified iPSC-derived cardiomyocytes in myocardial infarction
por: Rojas, Sebastian V., et al.
Publicado: (2017)

Analysis of Drug Effects on iPSC Cardiomyocytes with Machine Learning
por: Juhola, Martti, et al.
Publicado: (2020)

The Structural and the Functional Aspects of Intercellular Communication in iPSC-Cardiomyocytes
por: Kiss, Eva, et al.
Publicado: (2022)

Dynamic alternative polyadenylation during iPSC differentiation into cardiomyocytes
por: Yang, Yanbo, et al.
Publicado: (2022)

BRAP: a novel regulator of the cardiomyocyte cell cycle controlling both proliferation and survival?
por: Derks, Wouter, et al.
Publicado: (2020)

Generation of self-assembling cardiac organoids using hiPSC-derived cardiomyocytes
por: Künzel, Karolina, et al.
Publicado: (2022)

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes
por: Necela, Brian M., et al.
Publicado: (2017)

Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
por: Santoro, Rosaria, et al.
Publicado: (2019)

Space microgravity improves proliferation of human iPSC-derived cardiomyocytes
por: Rampoldi, Antonio, et al.
Publicado: (2022)

Gene Modulation with CRISPR-based Tools in Human iPSC-Cardiomyocytes
por: Han, Julie Leann, et al.
Publicado: (2023)

Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes
por: Sattler, Katherine, et al.
Publicado: (2019)

Rapid Assessment of Proarrhythmic Potential Using Human iPSC-Derived Cardiomyocytes
por: Geiger, Robert M., et al.
Publicado: (2020)

iPSC-Cardiomyocyte Models of Brugada Syndrome—Achievements, Challenges and Future Perspectives
por: Nijak, Aleksandra, et al.
Publicado: (2021)

Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes
por: Nijak, Aleksandra, et al.
Publicado: (2022)

Sarcomere Disassembly and Transfection Efficiency in Proliferating Human iPSC-Derived Cardiomyocytes
por: Yuan, Qianliang, et al.
Publicado: (2022)

Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes
por: Saraf, Anita, et al.
Publicado: (2021)

Human iPSC-Cardiomyocytes as an Experimental Model to Study Epigenetic Modifiers of Electrophysiology
por: Pozo, Maria R., et al.
Publicado: (2022)

ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes
por: Zech, Antonia T. L., et al.
Publicado: (2022)

Protocol to identify small molecules promoting rat and mouse cardiomyocyte proliferation based on the FUCCI and MADM reporters
por: Zheng, Lixia, et al.
Publicado: (2022)

Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation
por: Li, Wener, et al.
Publicado: (2020)

Co-culture with neonatal cardiomyocytes enhances the proliferation of iPSC-derived cardiomyocytes via FAK/JNK signaling
por: Ou, Dongbo, et al.
Publicado: (2016)

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes
por: Eschenhagen, Thomas, et al.
Publicado: (2015)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
por: Zuppinger, Christian, et al.
Publicado: (2017)

Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium
por: Weber, Marbod, et al.
Publicado: (2020)

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
por: Sharma, Arun, et al.
Publicado: (2020)

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
por: M. Feyen, Dries A., et al.
Publicado: (2020)

Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes
por: Yanagida, Shota, et al.
Publicado: (2021)

cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes
por: Mazgaoker, Savyon, et al.
Publicado: (2022)

iPSC-Derived Cardiomyocytes in Inherited Cardiac Arrhythmias: Pathomechanistic Discovery and Drug Development
por: Simons, Eline, et al.
Publicado: (2023)

RNA Expression Profiling of Human iPSC-Derived Cardiomyocytes in a Cardiac Hypertrophy Model
por: Aggarwal, Praful, et al.
Publicado: (2014)

Electrophysiological Characteristics of Human iPSC-Derived Cardiomyocytes for the Assessment of Drug-Induced Proarrhythmic Potential
por: Yamamoto, Wataru, et al.
Publicado: (2016)

Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation
por: Sharma, Arun, et al.
Publicado: (2018)

Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes
por: Ng, Kwong-Man, et al.
Publicado: (2018)

A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues
por: Pavlovic, Bryan J., et al.
Publicado: (2018)

Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes
por: Lapp, Hendrik, et al.
Publicado: (2017)

A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees
por: Ward, Michelle C, et al.
Publicado: (2019)

Assessment of temporal functional changes and miRNA profiling of human iPSC-derived cardiomyocytes
por: Kumar, Naresh, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_nncf9t60be8drsa26fl2743ab2