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Tandem four-component reaction for efficient synthesis of dihydrothiophene with substituted amino acid ethyl esters
The one-pot four-component reaction of aromatic aldehydes, malononitrile, 1,3-thiazolidinedione and ethyl glycinate hydrochloride in ethanol in the presence of triethylamine afforded trans-dihydrothiophene ureidoformamide derivatives in moderate to good yields. The other α-amino acid ethyl esters re...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081350/ https://www.ncbi.nlm.nih.gov/pubmed/35539758 http://dx.doi.org/10.1039/c8ra03605e |