Combination of Sildenafil and Ba(2+) at a Low Concentration Show a Significant Synergistic Inhibition of Inward Rectifier Potassium Current Resulting in Action Potential Prolongation

Sildenafil (Viagra) is a vasodilator mainly used in the treatment of erectile dysfunction. Atrial or ventricular fibrillation may rarely occur as a side effect during sildenafil therapy. Although changes in inward rectifier potassium currents including I (K1) are known to contribute to the pathogene...

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Detalles Bibliográficos
Autores principales: Macháček, Martin, Švecová, Olga, Bébarová, Markéta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081525/
https://www.ncbi.nlm.nih.gov/pubmed/35548367
http://dx.doi.org/10.3389/fphar.2022.829952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081525/
https://www.ncbi.nlm.nih.gov/pubmed/35548367
http://dx.doi.org/10.3389/fphar.2022.829952

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