A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder

A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadrupl...

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Detalles Bibliográficos
Autores principales: Zhou, Chun-Qiong, Li, Zi-Qi, Liao, Ting-Cong, Ma, Tian-Zhu, Chen, Shuo-Bin, Liang, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081585/
https://www.ncbi.nlm.nih.gov/pubmed/35540167
http://dx.doi.org/10.1039/c8ra03606c
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author Zhou, Chun-Qiong
Li, Zi-Qi
Liao, Ting-Cong
Ma, Tian-Zhu
Chen, Shuo-Bin
Liang, Yuan-Yuan
author_facet Zhou, Chun-Qiong
Li, Zi-Qi
Liao, Ting-Cong
Ma, Tian-Zhu
Chen, Shuo-Bin
Liang, Yuan-Yuan
author_sort Zhou, Chun-Qiong
collection PubMed
description A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes via end-stacking and external-binding modes.
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spelling pubmed-90815852022-05-09 A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder Zhou, Chun-Qiong Li, Zi-Qi Liao, Ting-Cong Ma, Tian-Zhu Chen, Shuo-Bin Liang, Yuan-Yuan RSC Adv Chemistry A novel phenanthroimidazole ethylenediamine Pt(ii) complex with coumarin derivative (1) was synthesized and showed higher affinity, selectivity and thermal stabilization for mixed-type dimeric G-quadruplexes (G2T1) over monomeric G-quadruplexes (G1) and duplex DNA. Complex 1 could bind to G-quadruplexes via end-stacking and external-binding modes. The Royal Society of Chemistry 2018-06-26 /pmc/articles/PMC9081585/ /pubmed/35540167 http://dx.doi.org/10.1039/c8ra03606c Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Zhou, Chun-Qiong
Li, Zi-Qi
Liao, Ting-Cong
Ma, Tian-Zhu
Chen, Shuo-Bin
Liang, Yuan-Yuan
A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title_full A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title_fullStr A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title_full_unstemmed A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title_short A novel square-planar Pt(ii) complex as a monomeric and dimeric G-quadruplex DNA binder
title_sort novel square-planar pt(ii) complex as a monomeric and dimeric g-quadruplex dna binder
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081585/
https://www.ncbi.nlm.nih.gov/pubmed/35540167
http://dx.doi.org/10.1039/c8ra03606c
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