Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs

The use of short interfering RNAs (siRNAs) as therapeutics holds great promise, but chemical modifications must first be employed to improve their pharmacokinetic properties. This study evaluates the in vitro cellular uptake and knock-down efficacy of cholesterol-modified triazole-linked siRNAs targ...

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Detalles Bibliográficos
Autores principales: Salim, Lidya, McKim, Chris, Desaulniers, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081628/
https://www.ncbi.nlm.nih.gov/pubmed/35540146
http://dx.doi.org/10.1039/c8ra03908a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081628/
https://www.ncbi.nlm.nih.gov/pubmed/35540146
http://dx.doi.org/10.1039/c8ra03908a

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