Design and virtual screening of novel fluoroquinolone analogs as effective mutant DNA GyrA inhibitors against urinary tract infection-causing fluoroquinolone resistant Escherichia coli

Fluoroquinolones (FQs) belong to the class of quinolone drugs that are used to treat Urinary tract infections (UTIs) through inhibition of E. coli DNA gyrase. Resistance to FQs poses a serious problem in the treatment against resistant strains of E. coli which are associated with Ser83 to Leu and As...

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Detalles Bibliográficos
Autores principales: Balasubramaniyan, Sakthivel, Irfan, Navabshan, Umamaheswari, Appavoo, Puratchikody, Ayarivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081776/
https://www.ncbi.nlm.nih.gov/pubmed/35540291
http://dx.doi.org/10.1039/c8ra01854e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081776/
https://www.ncbi.nlm.nih.gov/pubmed/35540291
http://dx.doi.org/10.1039/c8ra01854e

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