Clinically observed deletions in SARS‐CoV‐2 Nsp1 affect its stability and ability to inhibit translation

Nonstructural protein 1 (Nsp1) of SARS‐CoV‐2 inhibits host cell translation through an interaction between its C‐terminal domain and the 40S ribosome. The N‐terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID‐19 disease progression. Here,...

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Detalles Bibliográficos
Autores principales: Kumar, Pravin, Schexnaydre, Erin, Rafie, Karim, Kurata, Tatsuaki, Terenin, Ilya, Hauryliuk, Vasili, Carlson, Lars‐Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081967/
https://www.ncbi.nlm.nih.gov/pubmed/35434785
http://dx.doi.org/10.1002/1873-3468.14354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9081967/
https://www.ncbi.nlm.nih.gov/pubmed/35434785
http://dx.doi.org/10.1002/1873-3468.14354

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